Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Astrocyte reactivity signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Adenosine-Astrocyte Metabolic Reset | 0.557 | neurodegeneration | Sleep disruption as cause and consequenc |
| Mechanosensitive Ion Channel Reprogramming | 0.505 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
| Astroglial Gap Junction Coordination via Connexin-43 Phospho | 0.497 | neurodegeneration | Perivascular spaces and glymphatic clear |
| Astrocyte-Mediated Neuronal Epigenetic Rescue | 0.479 | neurodegeneration | Epigenetic reprogramming in aging neuron |
| Lipid Droplet Dynamics as Phenotype Switches | 0.463 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
| Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th | 0.455 | neurodegeneration | Neuroinflammation resolution mechanisms |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.557
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.623
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.552
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.554
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] | Yang J, Borchert A, Kuhn H | J Biol Chem | 2026 | 1 |
| PIEZO channels link mechanical forces to uterine contractions in parturition. [PMID:41231991] | Zhang Y, Kini SA, Mishkanian SA, Yarishk | Science | 2025 | 1 |
| Identification of mechanosensitive ion channel-related molecular subtypes and ke [PMID:40950697] | Zhang L, Wang L, Wang M, Peng K, Chen H, | Transl Cancer Res | 2025 | 1 |
| Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outf [PMID:41268978] | Redmon SN, Yarishkin O, Rudzitis CN, Lak | Invest Ophthalmol Vis Sci | 2025 | 1 |
| Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lin [PMID:39237833] | Schöbel A, Pinho Dos Reis V, Burkhard R, | Commun Biol | 2024 | 1 |
| Inflammation alters the expression and activity of the mechanosensitive ion chan [PMID:39789885] | Ren J, Zhan C, Lin Y | Eur J Orthod | 2024 | 1 |
| Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting C [PMID:36987924] | Cai W, Liu L, Shi X, Liu Y, Wang J, Fang | Circulation | 2023 | 1 |
| Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated [PMID:36323829] | Tong J, Lan XT, Zhang Z, Liu Y, Sun DY, | Acta Pharmacol Sin | 2023 | 1 |
| Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007] | Zong B, Yu F, Zhang X, Pang Y, Zhao W, S | Ageing Res Rev | 2023 | 1 |
| GJA1-20k and Mitochondrial Dynamics. [PMID:35399255] | Shimura D, Shaw RM | Front Physiol | 2022 | 1 |
| Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage. [PMID:36009491] | Kou Y, Geng F, Guo D | Biomedicines | 2022 | 1 |
| Lipid Stores and Lipid Metabolism Associated Gene Expression in Porcine and Bovi [PMID:32899450] | Kajdasz A, Warzych E, Derebecka N, Madej | Int J Mol Sci | 2020 | 1 |
| CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistan [PMID:32106859] | Zhang H, Deng T, Liu R, Ning T, Yang H, | Mol Cancer | 2020 | 1 |
| A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell re [PMID:31488706] | Packer JS, Zhu Q, Huynh C, Sivaramakrish | Science | 2019 | 1 |
| Metabolic asymmetry and the global diversity of marine predators. [PMID:30679341] | Grady JM, Maitner BS, Winter AS, Kaschne | Science | 2019 | 1 |
| A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)? [PMID:28224793] | Wang Z, DeWitt JC, Higgins CP, Cousins I | Environ Sci Technol | 2017 | 1 |
| Inhibition of connexin43 improves functional recovery after ischemic brain injur [PMID:25988944] | Li X, Zhao H, Tan X, Kostrzewa RM, Du G, | Glia | 2015 | 1 |
| Gene Expression by Mouse Inner Ear Hair Cells during Development. [PMID:25904789] | Scheffer DI, Shen J, Corey DP, Chen ZY | J Neurosci | 2015 | 1 |
| Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b [PMID:24293102] | Zhao Y, Bhattacharjee S, Jones BM, Hill | Mol Neurobiol | 2014 | 1 |
| Chapter 6: Structural variation and medical genomics. [PMID:23300412] | Raphael BJ | PLoS Comput Biol | 2012 | 1 |